AZD1775 Bound in WEE1 Kinase - Cover Art Submission - Maxwell Render
Alternative cover image re-rendered for permanent display in university of Colorado-AMC Graduate School offices.
Wee1 pathway schematic
AZD1775 Docking - Lightwave Render
KAC034 docking - Lightwave Render
Predicted binding of AZD1775
Predicted binding of 28
AZD1775 vs 28 compared
Wee1 is a protein that halts the progression of the cell cycle. Cancer cells rely on Wee1 to help them resist the toxic effects of chemotherapy. By inhibiting Wee1, we can kill drug-resistant cancer cells but the current drug in clinical trials (AZD1775, pictured here in orange) has toxicity issues due to off-target effects. Our compound (KAC034, in yellow) has greater potency against WEE1 than AZD1775, but has greatly reduced toxic side effects. For more information see https://www.ncbi.nlm.nih.gov/pubmed/29883531
